Protecting groups
are the derivatives
that are installed
temporarily to mask the
reactivity of a functional group in a
multifunctional compound to achieve a chemoselective reaction. The required
characteristics for a protecting group includes –
- Obtaining the
chemoselectivity in a subsequent
chemical reaction
- In
a compound containing multifunctional groups
when the chemical reaction
is to be carried out selectively
at one reactive site, other
reactive sites must be temporarily blocked.
- Introduction
and removal of the protective group must be efficient.
The
functional groups which are widely used for protection are Hydroxyl group (-OH), Carbonyl group (-C=O), Thiol group (-SH), Carboxylic
acid group (-COOH), Phosphate group
(-PO43-), Amino
group (-NH2) and Alkyne
derivative.
PROTECTION
OF HYDROXYL GROUP (-OH) :
The
following chart gives you a proper outline of various routes of protecting
Hydroxyl functional group.
